Endocrine Abstracts

With over 650 million people obese in 2016 and 2.8 million people dying a year from being overweight or obese, the obesity epidemic is now linked to more deaths worldwide than being underweight. This high mortality rate and disease burden are potentially preventable if risk factors such as unhealthy diet and physical inactivity were eliminated. The classification of obesity is defined as a Body Mass Index (BMI) equal to or above 30 kg/m2. Weight management services ...

Background: Primary hyperaldosteronism (PHA) typically manifests as resistant hypertension, hypokalaemia and metabolic alkalosis. We present a case of PHA who subsequently exposed type 4 renal tubular acidosis (RTA) after surgical intervention.Case history: A 62 year old man underwent investigation for chronic resistant hypertension, which had failed to respond to titration of three antihypertensive agents including Perindopril, Amlodipine and Doxazosin....

Background: Denosumab is a monoclonal antibody against RANK ligand used for the treatment of osteoporosis. Although clinical trials demonstrate that denosumab is highly effective at reducing fragility fractures in postmenopausal osteoporosis, there have been few studies looking at real world outcomes. Our primary aim was to assess the efficacy of denosumab in practice.Methods: We retrospectively formed a database of 257 patients seen in endocrinology out...